Volume 4, Issue 3 p. 273-290
Advanced Review

Noble metal nanoparticles in DNA detection and delivery

Xi-Jun Chen

Xi-Jun Chen

Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA

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Brenda L. Sanchez-Gaytan

Brenda L. Sanchez-Gaytan

Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA

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Zhaoxia Qian

Zhaoxia Qian

Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA

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So-Jung Park

Corresponding Author

So-Jung Park

Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA

Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USASearch for more papers by this author
First published: 04 January 2012
Citations: 51

Abstract

DNA-conjugated metal nanoparticles have attracted enormous attention for biological and medical applications, owing to their unusual DNA melting characteristics as well as unique optical and catalytic properties. The combination of these unique properties has not only led to the development of DNA-detection technologies with remarkably high selectivity and sensitivity, but also to the development of gene therapeutic agents with high efficacy and efficiency. In this review, we present a comprehensive coverage on their applications in detecting, manipulating, and delivering genes. WIREs Nanomed Nanobiotechnol 2012, 4:273–290. doi: 10.1002/wnan.1159

This article is categorized under:

  • Diagnostic Tools > Diagnostic Nanodevices
  • Diagnostic Tools > In Vitro Nanoparticle-Based Sensing
  • Diagnostic Tools > In Vivo Nanodiagnostics and Imaging