Early View e1538
Advanced Review

Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family

Chao-Yue Cui,

National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, China

Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

Contribution: Formal analysis (equal), Resources (equal), Writing - original draft (equal)

Search for more papers by this author
Qiwei Chen,

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

Department of Microbiology, and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Contribution: Formal analysis (equal), Visualization (equal), Writing - original draft (equal)

Search for more papers by this author
Qian He,

National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, China

Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

Contribution: Data curation (equal), Formal analysis (equal), Resources (equal), Validation (equal), Writing - original draft (equal)

Search for more papers by this author
Chong Chen,

Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, Jiangsu, China

Contribution: Data curation (equal), Formal analysis (equal), Writing - original draft (equal)

Search for more papers by this author
Rong-Min Zhang,

National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, China

Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

Contribution: Formal analysis (equal), Resources (equal), Writing - original draft (equal)

Search for more papers by this author
Youjun Feng,

Corresponding Author

Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, China

Department of Microbiology, and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Correspondence

Youjun Feng, Department of Microbiology, and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.

Email: fengyj@zju.edu.cn

Jian Sun, National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, 510642, China.

Email: jiansun@scau.edu.cn

Contribution: Conceptualization (lead), Formal analysis (equal), Funding acquisition (equal), Supervision (lead), Writing - original draft (lead), Writing - review & editing (lead)

Search for more papers by this author
Jian Sun,

Corresponding Author

National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, China

Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China

Correspondence

Youjun Feng, Department of Microbiology, and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.

Email: fengyj@zju.edu.cn

Jian Sun, National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, 510642, China.

Email: jiansun@scau.edu.cn

Search for more papers by this author
First published: 05 October 2021

Chao-Yue Cui and Qiwei Chen have contributed equally to this study.

Funding Information: This study was supported by the National Science Fund for Distinguished Young Scholar (32125003 to Youjun Feng), National Natural Science Foundation of China (31830001 to Youjun Feng), the Guangdong Major Project of Basic and Applied Basic Research (Grant 2020B0301030007), the Program for Innovative Research Team in the University of Ministry of Education of China (Grant IRT_17R39), the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (Grant 2019BT02N054), the 111 Project (Grant D20008), and Natural Science Foundation of Jiangsu Province, China (Grant BK20210803).

Edited by:: Cui Hua Liu, Editor

Funding information: National Science Fund for Distinguished Young Scholar, Grant/Award Number: 32125003; Guangdong Major Project of Basic and Applied Basic Research, Grant/Award Number: 2020B0301030007; Natural Science Foundation of Jiangsu Province, China, Grant/Award Number: BK20210803; Program for Innovative Research Team in the University of Ministry of Education of China, Grant/Award Number: IRT_17R39; 111 Project, Grant/Award Number: D20008; Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program, Grant/Award Number: 2019BT02N054; National Natural Science Foundation of China, Grant/Award Number: 31830001

Abstract

Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline-type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini-review might benefit better understanding of Tet(X)-mediated tigecycline resistance.

This article is categorized under:

  • Infectious Diseases > Genetics/Genomics/Epigenetics
  • Infectious Diseases > Environmental Factors
  • Infectious Diseases > Molecular and Cellular Physiology

Abstract

Probing the natural pool of Tet(X) tigecycline resistance.

DATA AVAILABILITY STATEMENT

Data sharing is not applicable to this article as no new data were created or analyzed in this study.