Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family
Chao-Yue Cui and Qiwei Chen have contributed equally to this study.
Funding Information: This study was supported by the National Science Fund for Distinguished Young Scholar (32125003 to Youjun Feng), National Natural Science Foundation of China (31830001 to Youjun Feng), the Guangdong Major Project of Basic and Applied Basic Research (Grant 2020B0301030007), the Program for Innovative Research Team in the University of Ministry of Education of China (Grant IRT_17R39), the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (Grant 2019BT02N054), the 111 Project (Grant D20008), and Natural Science Foundation of Jiangsu Province, China (Grant BK20210803).
Edited by:: Cui Hua Liu, Editor
Funding information: National Science Fund for Distinguished Young Scholar, Grant/Award Number: 32125003; Guangdong Major Project of Basic and Applied Basic Research, Grant/Award Number: 2020B0301030007; Natural Science Foundation of Jiangsu Province, China, Grant/Award Number: BK20210803; Program for Innovative Research Team in the University of Ministry of Education of China, Grant/Award Number: IRT_17R39; 111 Project, Grant/Award Number: D20008; Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program, Grant/Award Number: 2019BT02N054; National Natural Science Foundation of China, Grant/Award Number: 31830001
Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline-type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini-review might benefit better understanding of Tet(X)-mediated tigecycline resistance.
This article is categorized under:
- Infectious Diseases > Genetics/Genomics/Epigenetics
- Infectious Diseases > Environmental Factors
- Infectious Diseases > Molecular and Cellular Physiology
Probing the natural pool of Tet(X) tigecycline resistance.
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.