The steps involved in a Coronavirus infection are interconnected and exhibit complex kinetics, with some processes depending on each other, while others occur independently. Understanding the basic kinetics of major processes like translation, transcription, and virion assembly in the Coronavirus life cycle adds temporal resolution to the classical view. Notably, the translation of the initial gRNA must be inhibited to allow for its full-length transcription.

2′O methylation on rRNA affects ribosome function and generates ribosome heterogeneity, while m⁶A modification on mRNA dynamically regulates its stability and translation. This review describes the role of 2′O methylation of rRNA and m⁶A modification of mRNA, along with several RBPs regulating translation and its potential impact on neuronal function. Graphical abstract created using BioRender.